For the following client and order/supply, determine if the proposed dose is safe and calculate in milliliters how much to administer per dose. If the dose is not safe, enter 0. Round to the nearest tenth, if necessary. Enter numbers only.
Order: amoxicillin/clavulanate (Augmentin) 125 mg po q8h
Client: infant (1 year) weighing 10 kg
Supply: bottle of amoxicillin/clavulanate (Augmentin) labeled 125 mg/5 mL
Literature: Safe dose amoxicillin/clavulanate (Augmentin): 20 to 40 mg/kg/24 hours given q8h po
To determine if the proposed dose of amoxicillin/clavulanate (Augmentin) for the infant is safe and calculate the amount to administer per dose, we will follow these steps:
1. Calculate the safe dose range for the infant based on the literature:
Safe dose range: 20 to 40 mg/kg/24 hours
2. Calculate the safe dose range for the infant’s weight:
Weight of the infant: 10 kg
Safe dose range (mg/24 hours) = Weight (kg) × Dose range (mg/kg/24 hours)
Safe dose range (mg/24 hours) = 10 kg × (20 to 40 mg/kg/24 hours)
Safe dose range (mg/24 hours) = 200 mg to 400 mg
3. Calculate the safe dose per dose (q8h) for the infant:
The client’s order is for 125 mg po q8h.
Safe dose per dose (mg/q8h) = Safe dose range (mg/24 hours) / Number of doses in 24 hours (3 doses)
Safe dose per dose (mg/q8h) = (200 mg to 400 mg) / 3
4. Now, let’s calculate the safe dose per dose in milliliters (mL) using the available supply:
Supply: Amoxicillin/clavulanate (Augmentin) labeled 125 mg/5 mL
Safe dose per dose (mL/q8h) = Safe dose per dose (mg/q8h) / Concentration (mg/mL)
Safe dose per dose (mL/q8h) = [(200 mg to 400 mg) / 3] / 125 mg/5 mL
Safe dose per dose (mL/q8h) = [(200/3) mg] / (125/5) mg/mL
5. Calculate the safe dose per dose (mL/q8h):
Safe dose per dose (mL/q8h) = [(200/3) / (125/5)] mL
Safe dose per dose (mL/q8h) = [(200/3) * (5/125)] mL
Safe dose per dose (mL/q8h) ≈ 3.33 mL (rounded to the nearest tenth)
So, the safe dose of amoxicillin/clavulanate (Augmentin) for the infant weighing 10 kg is approximately 3.33 mL per dose to be administered every 8 hours (q8h). This dose falls within the safe dose range recommended in the literature.
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