Cite 3 scholarly resources
Pharmacotherapy has undergone significant transformations with the integration of genetic engineering in the manufacturing process of various medications. This essay explores a pharmacologic agent that leverages genetic engineering, its therapeutic applications, dosing, manufacturer, cost, genetic process, mechanism of action, and associated risks and side effects.
Name Brand: Enbrel®
Generic Name: Etanercept
Enbrel is utilized to treat autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. It also finds application in the management of moderate to severe plaque psoriasis.
Yes, Enbrel is FDA-approved for the mentioned indications.
A common dosing regimen for Enbrel in adults with rheumatoid arthritis is 50 mg subcutaneously once weekly.
Enbrel is manufactured by Amgen and Pfizer. The estimated monthly cost without insurance is approximately $1,300, according to GoodRx.
Enbrel is engineered through recombinant DNA technology. The gene responsible for encoding human tumor necrosis factor receptor is inserted into a living system, often bacterial cells, which then produce the receptor fusion protein. This protein is composed of the extracellular ligand-binding domain of the human tumor necrosis factor receptor linked to the Fc domain of human immunoglobulin G1 (IgG1). This fusion protein acts as a “decoy receptor,” binding to tumor necrosis factor and preventing its interaction with cell surface receptors.
Enbrel’s fusion protein works by binding to soluble tumor necrosis factor (TNF), preventing its interaction with cell surface receptors. This inhibits the inflammatory responses mediated by TNF and subsequently mitigates the immune system’s aberrant activation. The therapy helps modulate immune responses, reducing inflammation, and alleviating symptoms associated with autoimmune conditions.
Common side effects of Enbrel include injection site reactions, upper respiratory infections, and headache. However, there are also risks of serious infections, tuberculosis reactivation, malignancies, and demyelinating disorders that necessitate careful monitoring and patient education.
The integration of genetic engineering into drug manufacturing has revolutionized pharmacotherapy. Etanercept (Enbrel), a prominent example, employs genetic engineering to create a fusion protein that inhibits inflammatory responses mediated by tumor necrosis factor. By targeting the immune system’s underlying mechanisms, Enbrel effectively treats autoimmune conditions like rheumatoid arthritis. However, like all medications, it carries risks and side effects that necessitate careful monitoring and patient education. As genetic engineering continues to shape the landscape of pharmaceuticals, innovative treatments like Enbrel stand as remarkable achievements in enhancing patient care and quality of life.
As a renowned provider of the best writing services, we have selected unique features which we offer to our customers as their guarantees that will make your user experience stress-free.
Unlike other companies, our money-back guarantee ensures the safety of our customers' money. For whatever reason, the customer may request a refund; our support team assesses the ground on which the refund is requested and processes it instantly. However, our customers are lucky as they have the least chances to experience this as we are always prepared to serve you with the best.
Plagiarism is the worst academic offense that is highly punishable by all educational institutions. It's for this reason that Peachy Tutors does not condone any plagiarism. We use advanced plagiarism detection software that ensures there are no chances of similarity on your papers.
Sometimes your professor may be a little bit stubborn and needs some changes made on your paper, or you might need some customization done. All at your service, we will work on your revision till you are satisfied with the quality of work. All for Free!
We take our client's confidentiality as our highest priority; thus, we never share our client's information with third parties. Our company uses the standard encryption technology to store data and only uses trusted payment gateways.
Anytime you order your paper with us, be assured of the paper quality. Our tutors are highly skilled in researching and writing quality content that is relevant to the paper instructions and presented professionally. This makes us the best in the industry as our tutors can handle any type of paper despite its complexity.
Recent Comments