To calculate the mL of Vancomycin to be administered per dose, we need to determine the total amount of Vancomycin available in the vial after reconstitution and then divide it by the desired dose (200mg)

QUESTION

A nurse is preparing to administer Vancomycin 200mg IV every 6hrs to a school age child. Available is Vancomycin 500mg powder in a vial. The package insert instructs reconstituting the powder with 10mL of sterile water and 100mL of 0.9% sodium chloride solution to yield Vancomycin 5mg/mL. How many mL should the nurse administer per dose (Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trilling zero

ANSWER

To calculate the mL of Vancomycin to be administered per dose, we need to determine the total amount of Vancomycin available in the vial after reconstitution and then divide it by the desired dose (200mg).

Step 1: Calculate the total amount of Vancomycin in the vial after reconstitution.
The package insert states that 500mg of Vancomycin is reconstituted with 10mL of sterile water and 100mL of 0.9% sodium chloride solution to yield a concentration of 5mg/mL.

So, the total amount of Vancomycin in the vial after reconstitution can be calculated as follows:
Total amount of Vancomycin = 500mg + (10mL + 100mL) x 5mg/mL
Total amount of Vancomycin = 500mg + 110mL x 5mg/mL
Total amount of Vancomycin = 500mg + 550mg
Total amount of Vancomycin = 1050mg

Step 2: Determine the mL to be administered per dose (200mg).
Now, we need to calculate the mL of Vancomycin required to achieve a dose of 200mg.

Ml to be administered per dose = Desired dose (200mg) ÷ Concentration after reconstitution (5mg/mL)

Ml to be administered per dose = 200mg ÷ 5mg/mL
Ml to be administered per dose = 40mL

Therefore, the nurse should administer 40mL of reconstituted Vancomycin (at a concentration of 5mg/mL) to achieve the desired dose of 200mg per dose.